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Related Concept Videos

Intermolecular Forces03:13

Intermolecular Forces

61.9K
Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen...
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Intermolecular Forces in Solutions02:28

Intermolecular Forces in Solutions

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The formation of a solution is an example of a spontaneous process, a process that occurs under specified conditions without energy from some external source.
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Such a solution is called an ideal solution. A mixture of ideal gases (or gases such as helium and argon,...
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Noncovalent Attractions in Biomolecules02:35

Noncovalent Attractions in Biomolecules

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Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
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Van der Waals Interactions01:24

Van der Waals Interactions

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Atoms and molecules interact with each other through intermolecular forces. These electrostatic forces arise from attractive or repulsive interactions between particles with permanent, partial, or temporary charges. The intermolecular forces between neutral atoms and molecules are ion–dipole, dipole–dipole, and dispersion forces, collectively known as van der Waals forces.
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Intermolecular Forces and Physical Properties02:56

Intermolecular Forces and Physical Properties

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Intermolecular vs Intramolecular Forces03:00

Intermolecular vs Intramolecular Forces

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Intermolecular forces (IMF) are electrostatic attractions arising from charge-charge interactions between molecules. The strength of the intermolecular force is influenced by the distance of separation between molecules. The forces significantly affect the interactions in solids and liquids, where the molecules are close together. In gases, IMFs become important only under high-pressure conditions (due to the proximity of gas molecules). Intermolecular forces dictate the physical properties of...
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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

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Intermolecular interactions between β-cyclodextrin and water.

Tianxiang Guo1,2, Lingfeng Kong1,2, Junpeng Xu1,2

  • 1Hebei Key Lab of Power Plant Flue Gas Multi-Pollutants Control, Department of Environmental Science and Engineering, North China Power University Baoding 071003 PR China.

RSC Advances
|April 28, 2022
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Summary
This summary is machine-generated.

Intermolecular interactions between beta-cyclodextrin and water were analyzed. Water adsorption is exothermic and complex, involving cavity effects and hydrogen bonding, with adsorption being easier than desorption.

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Area of Science:

  • Physical Chemistry
  • Supramolecular Chemistry
  • Materials Science

Background:

  • Understanding beta-cyclodextrin (β-CD) interactions with water is crucial for drug delivery and molecular encapsulation.
  • The precise nature of these intermolecular forces influences the host-guest complexation efficiency.

Purpose of the Study:

  • To quantify the intermolecular interaction strength between β-cyclodextrin and water.
  • To elucidate the mechanisms governing water adsorption and desorption on β-cyclodextrin.

Main Methods:

  • Dynamic water adsorption experiments.
  • Thermogravimetric-Differential Scanning Calorimetry (TG-DSC) analysis.
  • Molecular modeling using MM2 force field calculations.

Main Results:

  • Water adsorption on β-cyclodextrin is an exothermic process with an activation energy of 7.4 kJ/mol.
  • Adsorption isotherms exhibited hysteresis, indicating non-physical adsorption due to cavity and hydrogen bonding effects.
  • Water desorption activation energy ranged from 35-45 kJ/mol, showing increased difficulty with less adsorbed water.

Conclusions:

  • The average intermolecular interaction strength between β-cyclodextrin and water was determined to be 67.5 kJ/mol.
  • Water adsorption is significantly easier than desorption, with desorption becoming more challenging as the water content decreases.
  • These findings provide insights into the complex interplay between β-cyclodextrin structure and water molecules.