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Updated: Sep 25, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Recent advances in intermolecular 1,2-difunctionalization of alkenes involving trifluoromethylthiolation
Li Yan-Mei1, Fu Jin-Feng1, He Long-Qiang1
1Institute of Chemical Industry and Environmental Engineering, Jiaozuo University Jiaozuo Henan 454000 China liyanmei0163@126.com.
Abstract:
Trifluoromethylthiolative difunctionalization of alkenes, a cheap and abundant feedstock, which installs a trifluoromethylthiol (SCF3) group and another unique functional group across the carbon-carbon double bonds, provides an ideal strategy for the preparation of β-functionalized alkyl trifluoromethyl sulfides and has become a hot topic recently. This review aims to summarize the major progress in this exciting research area, with particular emphasis on the mechanistic aspects of the reaction pathways.
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