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Updated: Sep 25, 2025

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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Morphine-Induced Fever: A Case Series.

Manisha Bhagat1, Saurabh Suman1, Kartik C Besra1

  • 1Anesthesiology, Rajendra Institute of Medical Sciences, Ranchi, IND.

Cureus
|April 28, 2022
PubMed
Summary
This summary is machine-generated.

Postoperative fever can be caused by opioid-induced pyrexia. In five cases, morphine administration led to fever, which resolved after switching to non-steroidal anti-inflammatory agents.

Keywords:
cervical cordcox-2 inhibitorsintervertebral discnon-steroidal antiinflammatory drugsopioid usepost operative feverpostopertive infectionprostheses and implantsvenous thromboembolism (vte)

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Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Postoperative fever is commonly caused by infection, but other etiologies exist.
  • Differential diagnosis of fever after surgery is crucial for appropriate patient management.

Observation:

  • Five patients developed fever following postoperative analgesia with morphine injection.
  • All other potential causes of fever were systematically excluded in these cases.

Findings:

  • Opioid-induced pyrexia is a potential complication of postoperative pain management.
  • Discontinuation of the offending opioid and substitution with non-steroidal anti-inflammatory agents resolved the fever in all reported cases.

Implications:

  • Clinicians should consider opioid-induced pyrexia in the differential diagnosis of postoperative fever.
  • Prompt recognition and management can prevent prolonged fever and unnecessary investigations.
  • Further research into the mechanisms of opioid-induced pyrexia is warranted.