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Outcomes of Very Preterm Neonates Born by Assisted Reproductive Techniques (ART): A Propensity Score Matched
Venkateshwarlu Vardhelli1, Rajendra Prasad Anne2, Srinivas Murki3
1Department of Neonatology, Fernandez Foundation, Hyderabad, Telangana.
Objective:
To compare outcomes of preterm neonates born through assisted reproduction techniques (ART) and non-ART conception.
Methods:
This retrospective cohort study included very preterm neonates (26 weeks to 31 weeks) admitted to our neonatal unit over a six year period from 2014 to 2019. The primary outcome was composite adverse outcome of mortality or any of the major morbidities i.e., intraventricular hemorrhage (IVH) grade ≤3, periventricular leukomalacia (PVL) grade ≤2, bronchopulmonary dysplasia (BPD) at 36 weeks, and retinopathy of prematurity (ROP) requiring treatment.
Result:
Total of 759 neonates (253 in ART group, 506 in non-ART group) were included after propensity score matching for gestational age, sex, and small for gestational age (SGA). Neonates in ART group had similar rates of composite adverse outcome [aOR (95% CI) 0.86 (0.55 - 1.36)], mortality [0.93, (0.53- 1.64)] BPD [1.18, (0.37 - 3.76)]; ROP requiring treatment [ 0.49 (0.14-1.71], and other morbidities.
Conclusion:
Very preterm neonates born through ART were not at increased risk of adverse neonatal outcomes.
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