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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Pulmonary Function in Children With Transfusion-Dependent Thalassemia and Its Correlation With Iron Overload

Aditi Baruah1, Jonali Bhattacharjee2

  • 1Department of Paediatrics, Assam Medical College and Hospital, Dibrugarh, Assam.

Indian Pediatrics
|April 28, 2022
PubMed

Insights

Pulmonary dysfunction is common in children with thalassemia, particularly a restrictive pattern. High serum ferritin levels, indicating excess body iron, significantly correlate with this lung impairment.

Area of Science:

  • Pediatric Pulmonology
  • Hematology
  • Medical Research

Background:

  • Transfusion-dependent thalassemia requires lifelong blood transfusions, leading to iron overload.
  • Iron overload can affect multiple organs, including the lungs, potentially impacting pulmonary function.

Purpose of the Study:

  • To evaluate the pulmonary function in children with transfusion-dependent thalassemia.
  • To investigate the relationship between serum iron status and pulmonary dysfunction patterns.

Main Methods:

  • A cross-sectional study included 66 children (5-18 years) with thalassemia receiving regular transfusions.
  • Pulmonary function was assessed using spirometry (FEV1, FVC, FEV1/FVC ratio).
  • Serum ferritin, C-reactive protein (CRP), and chest X-rays were analyzed.

Main Results:

  • 80.3% of participants had HbE/b-thalassemia.
  • 71.2% exhibited restrictive pulmonary dysfunction.
  • Significantly elevated serum ferritin levels (mean 5616 ng/mL) correlated with impaired pulmonary function (P<0.001).

Conclusions:

  • Restrictive pulmonary dysfunction is prevalent in children with thalassemia.
  • Body iron status, indicated by serum ferritin, is significantly associated with pulmonary impairment in these patients.
Abstract

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