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Updated: Sep 25, 2025

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
Late bacterial endocarditis after percutaneous atrial septal defect closure
Makiko Nishioka1, Kenji Hoshino1, Shinya Ugaki2
1Department of Pediatric Cardiology, Saitama Children's Medical Center, Saitama330-8777, Japan.
Infective endocarditis after percutaneous atrial septal defect closure is rare in children. This case highlights a late-stage infection in an 11-year-old girl due to incomplete device endothelialisation.
Area of Science:
- Cardiology
- Pediatric Cardiology
- Infectious Diseases
Background:
- Percutaneous closure of atrial septal defects (ASDs) is a common alternative to surgery.
- Infective endocarditis is a known complication of cardiac occluding devices.
- Late-stage endocarditis following pediatric ASD device closure is exceptionally rare.
Purpose of the Study:
- To report a rare case of late-stage bacterial endocarditis in a child after percutaneous ASD closure.
- To emphasize the importance of considering device-related complications even in pediatric patients.
Main Methods:
- Case report of an 11-year-old girl.
- Review of clinical presentation, diagnostic workup, and management.
- Focus on the timeline of endocarditis development post-procedure.
Main Results:
- The patient developed late-stage bacterial endocarditis.
- The complication was linked to incomplete endothelialisation of the closure device.
- This highlights a rare but serious potential adverse event.
Conclusions:
- Late-stage infective endocarditis can occur following percutaneous ASD closure in children.
- Incomplete endothelialisation may be a contributing factor.
- Vigilance for device-related infections is crucial in pediatric cardiology.
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