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Updated: Sep 25, 2025

Novel and Innovative Hybrid Technique for Type A Aortic Dissection
Published on: March 28, 2025
Alport syndrome: A case study of chronic type A aortic dissection
Hironobu Nishiori1, Tomoki Sakata1, Shin-Ichi Makino2
1Department of Cardiovascular Surgery, Chiba University Hospital, Chiba, Japan.
Abstract:
A 39-year-old woman with a history of Alport syndrome was admitted to our hospital for heart failure due to severe aortic regurgitation. Computed tomography revealed a chronic type A aortic dissection that required valve-sparing aortic root replacement. The pathological examination demonstrated that elastic fibers in the tunica media of the aortic wall are torn and severely disorganized. Immunostaining showed fragmented alpha 5 chains, indicating Alport syndrome. These findings imply Alport syndrome may have connective tissue vulnerability, rendering patients susceptible to the development of aortic disease at a young age.
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