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Updated: Sep 25, 2025

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
Published on: February 16, 2024
Environmental and genetic risk factors for gastric cancer
Dhavan Shah1, David Bentrem2,3
1Department of Surgery, Surgical Outcome and Quality Improvement Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Abstract:
Gastric cancer is a heterogeneous and prevalent disease. The traditional environmental exposures associated with an elevated risk of gastric cancer are less prevalent in the United States today. Genetic risks and risks associated with inflammation remain. Most cases are sporadic and familial clustering is observed in about 10% of the cases. Hereditary gastric cancer accounts for a very low percentage of cases. Here we review the genetic and environmental risk factors associated with the disease.
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