Intravenous therapy with gamma globulin

The availability of intravenous gamma globulin preparations that are safe and effective has revolutionized replacement therapy in those patients suffering primary or secondary hypogammaglobulinemia. The potential for controlling numerous autoimmune reactions with high-dose gamma globulin infusion is exciting and challenging. Unraveling the immunoregulatory mechanisms that interact with large doses of human IgG may teach us much about immunoregulation in general and the immunopathogenic mechanisms that lead to chronic disease for so many.