Jove
Visualize
Contact Us

Related Experiment Videos

The long Q-T interval and syndromes.

C E Kossmann

    Advances in Internal Medicine
    |January 1, 1987
    PubMed
    Summary

    Long Q-T syndrome (LQTS) involves acquired, congenital, and miscellaneous forms, each with distinct treatments. Understanding electrical sources of arrhythmias in LQTS is crucial for developing new therapies.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    ROLE OF MEDICAL SCHOOLS AND RESEARCH INSTITUTES IN RESEARCH TRAINING.

    A listing of research in the cardiovascular field·2014
    Same author

    EDUCATION AND TRAINING--SUMMARY.

    A listing of research in the cardiovascular field·2014
    Same author

    Relative importance of certain variables in the clinical determination of blood pressure.

    The American journal of medicine·2010
    Same author

    The rate of conduction in the human atrium.

    The Journal of clinical investigation·2010
    Same author

    Placement of cardiac patients in appropriately selected jobs.

    Salubridad y asistencia·2010
    Same author

    Substitution of the Einthoven triangle by a tetrahedron.

    Salubridad y asistencia·2010
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Cardiology
    • Electrophysiology
    • Molecular Biology

    Background:

    • Long Q-T syndrome (LQTS) presents clinically as acquired, congenital, or miscellaneous forms.
    • Therapies for LQTS vary based on etiology, targeting drugs for acquired forms and sympathetic activity for congenital forms.
    • Pathologic disparities in myocardial excitation-contraction coupling and sympathetic nervous system activity are implicated in LQTS arrhythmogenesis.

    Purpose of the Study:

    • To review the current understanding of the electrical mechanisms underlying arrhythmias in Long Q-T syndrome.
    • To explore potential alternative electrophysiological sources contributing to ventricular arrhythmias in LQTS.
    • To highlight the need for further clinical validation of proposed mechanisms and the development of novel therapeutic strategies.

    Main Methods:

    • Review of existing literature on LQTS pathophysiology and electrophysiology.
    • Analysis of proposed electrical mechanisms for arrhythmogenesis during Q-T and Q-U intervals.
    • Consideration of evidence from membrane-level studies (e.g., canine Purkinje fibers) and clinical observations.

    Main Results:

    • Current understanding points to disparities in myocardial repolarization and sympathetic overactivity as primary drivers of LQTS arrhythmias.
    • Alternative mechanisms, including altered ventricular activation, desynchronized repolarization, and afterdepolarizations, are proposed as potential contributors.
    • Limited clinical evidence exists for some proposed mechanisms, necessitating further investigation.

    Conclusions:

    • Further clinical research is essential to validate proposed electrophysiological mechanisms in LQTS.
    • Advancements in understanding LQTS arrhythmias will likely lead to improved management strategies for malignant ventricular arrhythmias.
    • Development of novel drugs targeting specific ion channel functions is an active area of investigation for LQTS treatment.

    Related Experiment Videos