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Correlation between polymorphism of vitamin D receptor TaqI and susceptibility to tuberculosis: An update
Bin Li1, Fei Wen2, Zhaofen Wang1
1Department of Public Health, Medical School of Qinghai University, Xining, China.
Background:
To investigate the association between TaqI polymorphism of the vitamin D receptor gene and tuberculosis (TB).
Methods:
A systematic search was performed in PubMed, Embase, Web of Science, Elsevier Science Direct, Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang, and Chongqing VIP databases for case-control study on TaqI gene polymorphism and TB susceptivity. Quality assessment of studies was performed using the Newcastle-Ottawa Scale for the methodological assessment of case-control studies, and R 4.0.5 software was used for the meta-analysis.
Results:
Among the 243 selected articles, 27 in the meta-analysis. The meta-analysis showed that the TaqI gene polymorphism allene gene model (t vs T, odds ratio [OR]: 1.12, 95% confidence interval [CI]: 0.99-1.27); dominant model (tt + tT vs TT, OR: 1.12, 95% CI: 0.98-1.29); recessive model (tt vs tT + TT, OR: 1.25, 95% CI: 1.03-1.51); codominant A (tt vs TT, OR: 1.37, 95% CI: 1.00-1.87); codominant B (tT vs TT, OR: 1.09, 95% CI: 0.99-1.19). And subgroup dominant model (tt + tT vs TT, OR: 1.27, 95% CI: 1.03-1.55) in Indianas, recessive model (tt vs tT + TT, OR: 1.49, 95% CI: 1.05-2.11) in Iranians, co-dominant B (tT vs TT, OR: 1.28, 95% CI: 1.03-1.59; OR: 1.42, 95% CI: 1.05-1.93) in Indianas and Iranians.
Conclusion:
This meta-analysis suggests a significant association between TB and the risk of TaqI in Iranians and Indians, but the vitamin D receptor polymorphism TaqI was not associated with Chinese. Thus, validation studies will be required to confirm these findings.
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