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Differences of inflammatory cytokine profile in patients with vulnerable plaque: A coronary CTA study

Caroline Roesner1, Markus Goeller1, Dorette Raaz-Schrauder1

  • 1Friedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Cardiology, Erlangen, Germany.

Atherosclerosis
|April 28, 2022
PubMed

Insights

Inflammatory biomarkers like IL-1a and IL-17 are linked to coronary plaque volume and vulnerable plaque. Monocyte chemoattractant protein-1 (MCP-1) may offer protective effects against atherosclerosis progression.

Area of Science:

  • Cardiovascular disease research
  • Inflammation and immunology
  • Biomarker discovery

Background:

  • Atherosclerosis involves various pro- and anti-inflammatory biomarkers.
  • Understanding these biomarkers' association with coronary plaque is crucial.

Purpose of the Study:

  • To analyze the association between different biomarkers and coronary plaque volume.
  • To investigate the link between biomarkers and vulnerable plaque subcomponents.

Main Methods:

  • Coronary CT angiography (CTA) was performed on 301 patients.
  • Semi-automated software quantified total plaque volume (TPV) and non-calcified plaque volume (NCPV).
  • Serum cytokine levels were analyzed and correlated with plaque characteristics.

Main Results:

  • High plaque burden correlated with increased levels of IFNƔ, IL-1a, IL-2, IL-4, IL-10, IL-17 and decreased levels of IL-8, MCP-1.
  • Multivariable analysis identified IL-1a and Eotaxin as positively associated with vulnerable plaque, while MCP-1 showed an inverse association.
  • Elevated IL-17 levels were observed in patients with high vulnerable plaque burden.

Conclusions:

  • Cytokine profiles differ significantly based on coronary plaque volume.
  • IL-1a and IL-17 may promote atherosclerosis, while MCP-1 might have protective effects.
  • Further longitudinal studies are needed to explore therapeutic targets.
Abstract

Keywords:
AtherosclerosisCoronary CT-angiographyInflammatory biomarkersInterleukinPlaque volumeVulnerable plaque

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