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Recent advances in passive immunotherapies for COVID-19: The Evidence-Based approaches and clinical trials

Pooya Farhangnia1, Shiva Dehrouyeh2, Amir Reza Safdarian3

  • 1Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran; Immunology Board for Transplantation and Cell-Based Therapeutics (ImmunoTACT), Universal Scientific Education and Research Network (USERN), Chicago, United States.

International Immunopharmacology
|April 28, 2022
PubMed

Insights

Passive immunotherapy offers a promising complementary approach for managing COVID-19, addressing challenges like vaccine efficacy and viral variants. This strategy focuses on reducing inflammation and viral load in patients.

Area of Science:

  • Immunology
  • Virology
  • Infectious Diseases

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the COVID-19 pandemic, with no definitive treatment.
  • COVID-19 vaccines face challenges including efficacy, adverse effects, and emerging variants, necessitating alternative management strategies.

Purpose of the Study:

  • To highlight passive immunotherapy and immunomodulation as complementary treatments for COVID-19.
  • To discuss the mechanisms and clinical trials of these approaches in managing COVID-19 patients.

Main Methods:

  • Review of passive immunotherapy and immunomodulation strategies.
  • Discussion of relevant clinical trials (CTs) for COVID-19 management.

Main Results:

  • Passive immunotherapy demonstrates potential in reducing inflammation, inhibiting cytokine storms, and preventing acute respiratory distress syndrome (ARDS).
  • These approaches contribute to viral neutralization, decreased viral load, and overall immunomodulation in COVID-19 patients.

Conclusions:

  • Passive immunotherapy presents a promising complementary therapeutic avenue for COVID-19 management.
  • Further investigation through clinical trials is crucial to establish the long-term efficacy and safety of these immunomodulatory strategies.
Keywords:
Acute Respiratory Disease SyndromeCOVID-19Cellular ImmunotherapyConvalescent Plasma (CP) TherapyImmunomodulationMonoclonal AntibodyPassive ImmunotherapySARS-CoV-2

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