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Updated: Sep 25, 2025

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

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Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcription

Shasha Chong1, Thomas G W Graham2, Claire Dugast-Darzacq3

  • 1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

Molecular Cell
|April 28, 2022
PubMed

Keywords:
EWS::FLI1Ewing sarcomaintrinsically disordered regionsliquid-liquid phase separationlow-complexity domainsmultivalent interactionsnucleolussingle-cell and single-molecule imagingtranscription factortranscriptional control

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