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Related Experiment Video

Updated: Sep 25, 2025

Quick Fluorescent In Situ Hybridization Protocol for Xist RNA Combined with Immunofluorescence of Histone Modification in X-chromosome Inactivation

Quick Fluorescent In Situ Hybridization Protocol for Xist RNA Combined with Immunofluorescence of Histone Modification in X-chromosome Inactivation

Published on: November 26, 2014

XIST in Brain Cancer.

Salma Eldesouki¹, Kamel A Samara¹, Rama Qadri¹

¹College of Medicine, University of Sharjah, Sharjah, UAE.

Clinica Chimica Acta; International Journal of Clinical Chemistry

|April 28, 2022

Summary

Long non-coding RNAs (lncRNAs) regulate cellular processes. The XIST lncRNA is implicated in brain tumor development and prognosis, affecting key cancer hallmarks like proliferation and chemoresistance.

Keywords:

Biomarker Brain Tumors Gliomas Long non-coding RNA Microrna Prognosis Tumorigenesis XIST

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Area of Science:

Molecular Biology
Genomics
Oncology

Background:

Long non-coding RNAs (lncRNAs) are abundant in the human genome and regulate gene expression.
X-inactive specific transcript (XIST) is a key lncRNA involved in X chromosome inactivation.
Emerging evidence links lncRNAs, including XIST, to various pathological conditions, notably cancer.

Purpose of the Study:

To review recent advancements in understanding the role of XIST in brain tumor development and prognosis.
To explore XIST's involvement in critical cancer hallmarks such as migration, proliferation, angiogenesis, chemoresistance, and apoptosis evasion.
To focus on the pathophysiological significance of XIST in gliomas.

Main Methods:

Literature review of recent studies on XIST and brain tumors.
Analysis of XIST's functional roles in different types of brain neoplasms.
Emphasis on experimental and clinical findings related to XIST in gliomas.

Main Results:

XIST plays a significant pathophysiological role in brain tumor progression.
XIST influences key cellular processes including migration, proliferation, angiogenesis, and chemoresistance.
Dysregulation of XIST is associated with the prognosis of various brain tumors, especially gliomas.

Conclusions:

XIST is an emerging molecular player in the pathogenesis and progression of brain tumors.
Targeting XIST may offer novel therapeutic strategies for brain cancer treatment.
Further research into XIST's mechanisms in gliomas is crucial for clinical translation.