The role of oxytocin in modulating self-other distinction in human brain: a pharmacological fMRI study

Self-other distinction is crucial for human interaction. Although with conflicting results, studies have found that oxytocin (OT) sharpens the self-other perceptual boundary. However, little is known about the effect of OT on self-other perception, especially its neural basis. Moreover, it is unclear whether OT influences self-other discrimination when the other is a child or an adult. This double-blind, placebo-controlled study investigated the effect of OT on self-face perception at the behavioral and neural levels. For the stimuli, we morphed participants' faces and child or adult strangers' faces, resulting in 4 conditions. After treatment with either OT or placebo, participants reported whether a stimulus resembled themselves while being scanned using functional magnetic resonance imaging (fMRI). Behavioral results showed that people judged adult-morphed faces better than child-morphed faces. Moreover, fMRI results showed that the OT group exhibited increased activity in visual areas and the inferior frontal gyrus for self-faces. This difference was more pronounced in the adult-face condition. In multivariate fMRI and region of interest analyses, better performance in the OT group indicated that OT increased self-other distinction, especially for adult faces and in the left hemisphere. Our study shows a significant effect of OT on self-referential processes, proving the potential effect of OT on a left hemisphere self-network.