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Updated: Sep 25, 2025
Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb
Published on: January 17, 2025
Systematic review of squamous cell carcinoma of the gallbladder
Hideo Takahashi1, Aiswarya Irri2, Yaniv Fenig3
1Department of Surgery, Section of Hepatobiliary Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Surgery, Mount Sinai South Nassau, Oceanside, NY, USA.
Background:
Although gallbladder cancer is the most common biliary tract malignancy, squamous cell carcinoma of the gallbladder (GBSCC) is extremely uncommon, comprising approximately 1-4% of all malignant gallbladder tumors. Given its rare incidence, there are currently no established treatment guidelines for GBSCC.
Methods:
We reviewed the current data available through a comprehensive search of PubMed/MEDLINE and Embase.
Results:
Although the clinical presentations of GBSCC and gallbladder adenocarcinoma (GBAC) are similar, GBSCCs are oftentimes larger and present with a higher histologic grade and more advanced pathological stage. Due to these aggressive features, the overall prognosis of GBSCC is significantly worse than GBAC, even after R0 resection.
Conclusion:
A combination of radical cholecystectomy with negative surgical margins along with systemic chemotherapy and/or radiotherapy appears to be the best treatment strategy based on the current limited literature. Mutational profiling using next-generation sequencing (NGS) can help clinicians identify and treat actionable mutations of this rare tumor.
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