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Why succinate? Physiological regulation by a mitochondrial coenzyme Q sentinel

Michael P Murphy1,2, Edward T Chouchani3,4

  • 1Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. mpm@mrc-mbu.cam.ac.uk.

Nature Chemical Biology
|April 28, 2022
PubMed
Summary

Succinate, a citric acid cycle metabolite, acts as a signaling molecule. Its levels reflect mitochondrial redox state, communicating cellular energy status throughout the body.

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