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Updated: Sep 25, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Manganese-Catalysed Deuterium Labelling of Anilines and Electron-Rich (Hetero)Arenes
Florian Bourriquen1, Nils Rockstroh1, Stephan Bartling1
1Leibniz-Institut für Katalyse e.V., Albert-Einstein-Straße 29a, 18059, Rostock, Germany.
Abstract:
There is a constant need for deuterium-labelled products for multiple applications in life sciences and beyond. Here, a new class of heterogeneous catalysts is reported for practical deuterium incorporation in anilines, phenols, and heterocyclic substrates. The optimal material can be conveniently synthesised and allows for high deuterium incorporation using deuterium oxide as isotope source. This new catalyst has been fully characterised and successfully applied to the labelling of natural products as well as marketed drugs.
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