Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

307
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
307
Seizures: Classification01:13

Seizures: Classification

630
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
630
Long-term Potentiation01:35

Long-term Potentiation

55.9K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
55.9K
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

540
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
540
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

716
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
716

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Epidural spinal cord stimulation in hereditary spastic paraplegia: preliminary results].

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko·2026
Same author

[Guidelines for clinical electroencephalography: Russian professional community development and consensus building].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2026
Same author

[Prolactin-secreting pituitary carcinomas with intra- and extracranial metastasis: case report and review].

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko·2025
Same author

Exploring Pathways for Pain Relief in Treatment and Management of Lumbar Foraminal Stenosis: A Review of the Literature.

Brain sciences·2024
Same author

Quantifying Lumbar Foraminal Volumetric Dimensions: Normative Data and Implications for Stenosis-Part 2 of a Comprehensive Series.

Medical sciences (Basel, Switzerland)·2024
Same author

[Supratentorial neuroepithelial tumor with PLAGL1 gene fusion - a new type of morphologically variable pediatric brain neoplasm defined by a distinct DNA methylation class. A case report and literature review].

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko·2024
Same journal

[The role of the cerebellum in the coordination of brain activity and the development of autism spectrum disorders].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2026
Same journal

[A clinical case of anxiety-hypochondriacal depression with extensive somatized symptoms in the elderly].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2026
Same journal

[De novo variant in the ATP2B2 gene as a cause of neuropsychiatric developmental disorder].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2026
Same journal

[Electroencephalographic predictors of olfactory stimulus discrimination in COVID-19 survivors].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2026
Same journal

[Effect of long-term carbamazepine therapy on bone metabolism in women with epilepsy].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2026
Same journal

[Glial-derived neurotrophic factor and neuropsychological status in COVID-19 survivors].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2026
See all related articles

Related Experiment Video

Updated: Sep 25, 2025

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

981

[Long-term epilepsy-associated tumors].

D N Kopachev1, L V Shishkina2, A M Shkatova2

  • 1Research Center of Neurology, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|April 29, 2022
PubMed
Summary
This summary is machine-generated.

Long-term epilepsy-associated tumors (LEAT) are a common cause of drug-resistant epilepsy. Diagnosis and surgical treatment require careful histological and radiological evaluation to differentiate them from aggressive tumors.

Keywords:
DNETepilepsygangliogliomasurgerytumor

More Related Videos

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

12.6K
Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
07:07

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

Published on: February 10, 2020

10.7K

Related Experiment Videos

Last Updated: Sep 25, 2025

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

981
Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

12.6K
Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
07:07

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

Published on: February 10, 2020

10.7K

Area of Science:

  • Neurology
  • Neurosurgery
  • Oncology

Background:

  • Benign glioneuronal tumors are a significant cause of adult drug-resistant epilepsy.
  • Long-term epilepsy-associated tumors (LEAT) are characterized by slow growth and cortical localization.

Purpose of the Study:

  • To review diagnostic methods for epileptogenic tumors.
  • To discuss the surgical management of LEAT.

Main Methods:

  • Literature search of the PubMed database.
  • Inclusion of clinical experience.

Main Results:

  • LEAT are the second leading cause of drug-resistant epilepsy in adults.
  • Key features include slow growth (>2 years), cortical location, and long epilepsy history.
  • Seizure freedom may require more than simple tumor removal due to epileptogenic zone spread.

Conclusions:

  • LEAT generally show low proliferative activity.
  • Histological and immunohistochemical analysis is crucial for differentiating LEAT from aggressive glial tumors.