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Updated: Sep 25, 2025
12:09
Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics
Published on: April 19, 2024
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Numerical modeling and development of a dual lung simulator using partitioned fluid-structure interaction approach
Rahul Kumar1, Sulekh Tokas1, Vijay Hadda2
1Department of Chemical Engineering, Indian Institute of Technology Delhi, New Delhi, India.
Summary
This study developed a numerical model for dual test lungs to evaluate mechanical ventilator performance. Higher lung compliance reduces peak pressure and stress, aiding in new ventilator design testing.
Area of Science:
- Biomedical Engineering
- Computational Fluid Dynamics
- Respiratory Mechanics
Background:
- Mechanical ventilators require rigorous testing before patient use.
- Test lungs are crucial for assessing ventilator behavior and lung mechanics.
- Existing methods may not fully capture complex lung dynamics.
Purpose of the Study:
- To develop and validate a numerical model of dual test lungs.
- To utilize a partitioned fluid-structure interaction (FSI) approach.
- To compare model predictions with experimental data for volume-controlled ventilation.
Main Methods:
- Development of a dual test lung numerical model.
- Implementation of the partitioned fluid-structure interaction (FSI) approach.
- Validation against experimental data for volume-controlled ventilation at various breathing rates and tidal volumes.
Main Results:
- Increased lung compliance (tidal volume/pressure rise) reduces peak pressure rise.
- Peak pressure observed: 44.73 cm H2O (10 ml/cm H2O compliance), 27.45 cm H2O (21 ml/cm H2O), and 14 cm H2O (39 ml/cm H2O) at 600 ml tidal volume.
- Lower compliance (10 ml/cm H2O) resulted in higher peak von-Mises stress (498 kPa) compared to higher compliance (39 ml/cm H2O).
Conclusions:
- The numerical model accurately simulates test lung behavior.
- Computational modeling can effectively investigate lung mechanics for spontaneous and ventilated breathing.
- This model serves as a basis for testing novel mechanical ventilator designs.
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