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Updated: Sep 25, 2025

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
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Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

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Indirect treatment comparison of idecabtagene vicleucel versus conventional care in triple-class exposed multiple

Nina Shah1, Ali Mojebi2, Dieter Ayers2

  • 1Division of Hematology & Oncology, University of California, San Francisco, CA 94143, USA.

Journal of Comparative Effectiveness Research
|April 29, 2022
PubMed

Aim: To compare the efficacy of idecabtagene vicleucel (ide-cel, bb2121) versus conventional care (CC) in triple-class exposed relapsed and refractory multiple myeloma (RRMM) patients. Patients & methods: A matching-adjusted indirect comparison was conducted using individual patient-level data from the pivotal, phase II, single-arm KarMMa trial (NCT03361748) and aggregate-level data from MAMMOTH, the largest independent observational study of CC in heavily pretreated RRMM patients. Results: Ide-cel improved overall response rate (odds ratio: 5.30; 95% CI: 2.96-9.51), progression-free survival (hazard ratio: 0.50; 95% CI: 0.36-0.70) and overall survival (hazard ratio: 0.37; 95% CI: 0.25-0.56) versus CC. Conclusion: These results suggest ide-cel offers improvements in clinical outcomes relative to CC in this heavily pretreated RRMM population.

Keywords:
CAR T cell therapyconventional careidecabtagene vicleucelmatching-adjusted indirect comparisonoutcomes researchrelapsed and refractory multiple myelomatriple-class exposed

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