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Related Concept Videos

Feedback Loops01:01

Feedback Loops

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In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
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Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
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Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
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Updated: Sep 25, 2025

Analysis of Circadian Photoresponses in Drosophila Using Locomotor Activity
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The author replies

Guha Krishnaswamy1

  • 1Department of Internal Medicine, Section of Pulmonary, Critical Care and Allergy, Section of Infectious Diseases, Wake Forest University School of Medicine, Winston-Salem, NC.

Critical Care Medicine
|April 29, 2022
PubMed
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No abstract available in PubMed .

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