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Related Experiment Video

Updated: Sep 25, 2025

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice
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Efficacy of Premedication Protocol without Ranitidine for Taxane Regimen: A Multicenter Non-Randomized Historical

Chaichana Chantharakhit1, Tanarat Ruchakorn2, Somprattana Mungkornkaew3

  • 1Division of Medical Oncology, Department of Internal Medicine, Buddhasothorn Hospital, Chachoengsao, Thailand.

Asian Pacific Journal of Cancer Prevention : APJCP
|April 29, 2022
PubMed
Summary
This summary is machine-generated.

Omitting ranitidine from chemotherapy premedication is safe for taxane regimens. This study found no significant difference in hypersensitivity reactions (HSRs) when ranitidine was excluded, supporting its removal from protocols.

Keywords:
Hypersensitivity reactions (HSRs)PremedicationRanitidinetaxane

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Area of Science:

  • Oncology
  • Clinical Pharmacology
  • Pharmacovigilance

Background:

  • Hypersensitivity reactions (HSRs) are a concern during taxane chemotherapy.
  • Standard premedication protocols often include ranitidine to mitigate HSRs.

Purpose of the Study:

  • To evaluate the efficacy and safety of omitting ranitidine from premedication in patients receiving taxane chemotherapy.
  • To compare the incidence of immediate HSRs between patients with and without ranitidine in their premedication.

Main Methods:

  • Multicenter, ambispective, non-randomized historical controlled cohort study.
  • Comparison of HSR incidence in patients receiving a modified (ranitidine-free) versus standard (ranitidine-containing) premedication protocol.
  • Multilevel regression analysis with random-effects model to compare HSR rates.

Main Results:

  • A total of 441 patients were analyzed (221 modified, 220 standard).
  • HSR incidence was 0.78% in the modified group and 0.52% in the standard group.
  • No statistically significant difference in HSR incidence was observed between the groups (p=0.30).

Conclusions:

  • Omitting ranitidine from the premedication protocol for taxane chemotherapy is safe.
  • The rate of HSRs is similar whether ranitidine is included or omitted.
  • Provides evidence-based support for modifying premedication protocols.