Memorial lecture: Verzár's ideas on the age-dependent protein cross-linking in the light of the present knowledge

This lecture was aimed to commemorate the centenary of the birthday (18 September 1886) of Fritz Verzár, one of the most important European founders of experimental gerontology. He was an exceptionally creative scientist who contributed considerably to the development of physiology in this century: he achieved important results in the fields of intestinal absorption, in the adrenal gland's function, and finally, from 1952 until his death (1979), he was creator, promotor and one of the best leaders of experimental gerontology. His idea about the age-dependent cross-linking of protein molecules as a general cause of cell aging--studied by him mainly using the collagen as a model, however, extended also to the nucleoproteins--was a pioneer's work. Yet, its significance was not immediately recognized, the contemporary scientists could not interpret his thoughts in the terms of test-tube biochemistry. However, about a decade later, in the sixties and afterwards, an increasing body of evidence has been accumulated indicating that Verzár was right: the most general age-dependent alteration of the proteins in the living systems known so far is a posttranslational modification of their structure and conformation due to the aggressive effects of the oxygen free radicals. Consequences of these thoughts are being realized nowadays in theory and practice. The present generation of scientists expresses its respect and recognition to Fritz Verzár whose life and activity have been teaching us that aging can be understood, if we find the proper theoretical approach to it.