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Updated: Sep 25, 2025
Isolation and Derivation of Mouse Embryonic Germinal Cells
Published on: October 22, 2009
In Vitro Differentiation of Murine Embryonic Stem Cells (ESCs) into Primordial Germ Cell-like Cells (PGCLCs)
Han-Pin Pui1,2, Qiaolin Deng3,4
1Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Abstract:
The ability to generate primordial germ cell-like cells (PGCLCs) from murine embryonic stem cells (ESCs) has enabled in vitro investigation of the molecular mechanisms regulating this process without the use of a mouse model. Here we describe the procedures from the culture of ESCs to the detection of PGCLCs in the embryoid bodies (spheroids).
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