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Updated: Sep 25, 2025

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
Published on: May 3, 2018
Cyclin-dependent kinases in breast cancer: expression pattern and therapeutic implications
Shazia Sofi1, Umar Mehraj1, Hina Qayoom1
1Department of Bioresources, School of Biological Sciences, University of Kashmir, Hazratbal, Srinagar, Jammu and Kashmir, 190006, India.
Cyclin-dependent kinases (CDKs) drive breast cancer cell proliferation and metastasis. Inhibiting CDKs offers a promising therapeutic strategy to control tumor growth and improve patient outcomes.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Therapeutics
Background:
- Breast cancer (BC) remains a leading cause of cancer-related deaths in women globally.
- Cell cycle dysregulation, particularly involving cyclin-dependent kinases (CDKs), is a key driver of uncontrolled cancer cell proliferation.
- Tumor heterogeneity and chemoresistance necessitate novel therapeutic targets for effective breast cancer management.
Purpose of the Study:
- To provide a comprehensive overview of the role of CDKs in breast cancer progression and metastasis.
- To review recent advancements in CDK-modulating therapeutics for malignancies.
- To explore the expression patterns and prognostic significance of CDKs in breast cancer patients.
Main Methods:
- Literature review of studies on cyclin-dependent kinases (CDKs) in breast cancer.
- Analysis of CDK expression patterns and their prognostic implications.
- Exploration of therapeutic strategies involving CDK inhibitors and their interaction with TGF-β signaling.
Main Results:
- CDKs and cyclins are critical in regulating the cell cycle and are implicated in tumor cell proliferation and metastasis.
- CDK inhibitors demonstrate therapeutic potential by modulating the cell cycle and inhibiting tumor progression.
- The expression and prognostic significance of CDKs in breast cancer patients have been investigated.
Conclusions:
- Targeting cyclin-dependent kinases (CDKs) represents a viable therapeutic approach for breast cancer treatment.
- Understanding CDK modulation, including its implications with TGF-β signaling, is crucial for developing effective breast cancer therapies.
- Further research into CDK inhibitors may lead to improved management of aggressive and chemoresistant breast cancers.
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