Interictal High Gamma Oscillation Regularity as a Marker for Presurgical Epileptogenic Zone Localization

Area of Science:

• Neuroscience
• Epileptology
• Medical Imaging

Background:

• Accurate presurgical localization of the epileptogenic zone is crucial for effective epilepsy surgery.
• Previous research indicates a link between interictal high gamma oscillation regularity (GOR) and epileptogenicity.

Purpose of the Study:

• To evaluate if preoperative GOR analysis with high-density electroencephalography (HD-EEG) enhances epileptogenic focus localization accuracy.
• To determine if this method improves postoperative seizure control.

Main Methods:

• GOR was calculated from HD-EEG data in 21 epilepsy surgery patients.
• Low-resolution brain electromagnetic tomography identified high GOR sources.
• Findings were compared with conventional localization methods and seizure outcomes.

Main Results:

• All patients who underwent resection of identified high GOR areas became seizure-free.
• GOR on HD-EEG showed high concordance with source estimation of interictal discharge and SPECT.
• GOR analysis was particularly useful in nonlesional temporal lobe epilepsy cases.

Conclusions:

• Interictal high GOR detected by HD-EEG is a highly effective marker for presurgical localization of the epileptogenic zone.
• This technique shows promise for improving surgical planning and patient outcomes in epilepsy.