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A tale of antiviral counterattacks in rotavirus infection

Arkadeb Bhuinya1, Debashree Dass1, Anwesha Banerjee1

  • 1Division of Virology, ICMR-National AIDS Research Institute, Pune, MH, India.

Microbiological Research
|April 29, 2022
PubMed

Insights

New antiviral drugs derived from natural sources show promise against human rotavirus (HRV) gastroenteritis in children. These RNA-silencing therapies target host and viral factors to combat HRV infection, addressing a critical gap in treatment options.

Area of Science:

  • Virology
  • Molecular Biology
  • Drug Discovery

Background:

  • Human rotaviruses (HRV) are a leading cause of severe infantile gastroenteritis globally.
  • Existing rotavirus vaccines are effective but do not address treatment for infected individuals.
  • There is a significant unmet need for approved antiviral agents against rotavirus infections.

Purpose of the Study:

  • To review recent advancements in naturally derived, RNA-silencing-based drug substances for treating rotavirus infections.
  • To explore the mechanisms by which these agents exhibit anti-rotaviral activity.
  • To highlight their potential in combating rotavirus pathogenesis.

Main Methods:

  • Literature review of recent studies on RNA-silencing therapies and natural product-derived antivirals.
  • Analysis of research focusing on host and viral targets of anti-rotaviral agents.
  • Synthesis of information on the development and efficacy of novel therapeutic strategies.

Main Results:

  • Naturally derived RNA-silencing agents demonstrate significant anti-rotaviral activity.
  • These therapies effectively target critical host and/or viral factors involved in rotavirus replication and pathogenesis.
  • Early research indicates potential for these agents as novel therapeutic interventions.

Conclusions:

  • RNA-silencing-based drugs derived from natural sources represent a promising avenue for rotavirus treatment.
  • Targeting host and viral factors offers a versatile strategy to combat rotavirus gastroenteritis.
  • Further development of these agents could address the current lack of effective antiviral therapies for rotavirus infections.

Keywords:
AntiviralMicroRNARNAiRotavirusVirus-host interaction

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