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Correlation of D-dimer and Outcomes in COVID-19 Patients

Hannah M Nemec1, Allison Ferenczy1, Benjamin D Christie1

  • 1Department of Trauma/Surgical Critical Care, The Medical Center Navicent Health and School of Medicine, 5225Mercer University, Macon, GA, USA.

The American Surgeon
|April 29, 2022
PubMed

Insights

Higher D-dimer levels in COVID-19 patients correlate with increased risk of intubation and mortality. Monitoring D-dimer trends can help physicians intervene early to improve patient outcomes.

Area of Science:

  • Medical Research
  • Infectious Diseases
  • Clinical Pathology

Background:

  • The COVID-19 pandemic has prompted extensive research into patient outcomes and predictive factors.
  • Plasma D-dimer levels are emerging as a significant prognostic indicator in coronavirus disease 2019 (COVID-19) patients.
  • Understanding laboratory data correlations is crucial for managing hospitalized COVID-19 cases.

Purpose of the Study:

  • To investigate the association between D-dimer levels and clinical outcomes in hospitalized COVID-19 patients.
  • To determine if admission and peak D-dimer values correlate with adverse events such as intubation and mortality.
  • To explore the potential of D-dimer monitoring for early intervention strategies.

Main Methods:

  • Retrospective analysis of 97 inpatient COVID-19 positive patients admitted between March and May 2020.
  • Collected and analyzed admission and peak D-dimer values.
  • Correlated D-dimer levels with patient outcomes, including intubation and mortality.

Main Results:

  • The study included 97 patients with a mean age of 63.2 years.
  • Median admission D-dimer was 2.35 ug/mL, and median peak D-dimer was 2.74 ug/mL, with an average time to peak of 3.2 days.
  • Patients requiring intubation exhibited significantly higher admission D-dimer levels (3.79 ug/mL) compared to those not intubated (1.62 ug/mL).

Conclusions:

  • Elevated admission and peak D-dimer levels are linked to poorer clinical outcomes in COVID-19 patients.
  • Higher D-dimer values are associated with increased rates of intubation and mortality.
  • Early monitoring of D-dimer trends may facilitate timely medical intervention to prevent severe outcomes.
Abstract

Keywords:
COVID-19D-dimerthrombolytics

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