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Chronic inflammation and calciphylaxis.

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Calciphylaxis, a rare condition often seen in kidney disease patients, can affect transplant recipients. Chronic inflammation, potentially from infection, may drive calciphylaxis progression, even with functioning grafts.

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Area of Science:

  • Nephrology
  • Transplant Surgery
  • Dermatology

Background:

  • Calciphylaxis, or calcific uremic arteriolopathy, is a rare vascular complication.
  • It predominantly affects patients with end-stage kidney disease.

Observation:

  • A simultaneous kidney-pancreas transplant recipient with functioning grafts developed biopsy-proven calciphylaxis.
  • The patient presented with chronic inflammation attributed to a persistent infection.

Findings:

  • Despite various treatments, the patient experienced disease progression, necessitating multiple amputations.
  • This case highlights chronic inflammation as a potential driver of calciphylaxis in transplant patients.

Implications:

  • Calciphylaxis should be considered in transplant recipients with painful, non-healing ulcers.
  • Early recognition and management of underlying chronic inflammation are crucial.