[Clinical guidelines «Polycystic Ovary Syndrome»]

Area of Science:

• Endocrinology
• Genetics
• Reproductive Medicine

Background:

• Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder with polygenic and epigenetic underpinnings.
• Clinical manifestations, diagnostic approaches, and therapeutic strategies for PCOS evolve throughout a woman's life.
• PCOS is characterized by a multifaceted presentation including reproductive, metabolic, and psychological disturbances.

Purpose of the Study:

• To provide evidence-based clinical recommendations for managing Polycystic Ovary Syndrome (PCOS).
• To guide healthcare professionals in diagnosing and treating PCOS across different life stages.
• To standardize PCOS management based on the quality and quantity of supporting scientific evidence.

Main Methods:

• Systematic review and evidence grading of existing studies on PCOS.
• Analysis of clinical data stratified by patient age and disease progression.
• Consensus development based on the reliability of evidence and persuasiveness of recommendations.

Main Results:

• PCOS exhibits distinct clinical phenotypes, diagnostic criteria, and treatment considerations depending on the patient's life stage.
• Reproductive, metabolic, and psychological symptoms are key components in the comprehensive assessment of PCOS.
• Recommendations are categorized by evidence level and persuasiveness to support clinical decision-making.

Conclusions:

• Clinical guidelines for PCOS must account for its dynamic nature and varying presentation across the lifespan.
• A multidisciplinary approach is essential for managing the reproductive, metabolic, and psychological facets of PCOS.
• Evidence-based recommendations, graded by reliability, are crucial for optimizing PCOS patient care.