Related Experiment Video
Updated: Aug 3, 2026
Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
Published on: December 13, 2019
Comparative Analysis of Left Ventricular Geometry in Adult Nigerians with and without Chronic Kidney Disease: Results
A M Adeoye1,2, B T Osibowale1, O Adebayo1
1Department of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
Insights
Chronic kidney disease (CKD) patients exhibit higher rates of abnormal left ventricular geometry and function. Lower estimated glomerular filtration rate (eGFR) is linked to increased left ventricular mass, highlighting the need for early cardiovascular risk management in CKD.
Area of Science:
- Cardiology
- Nephrology
Background:
- Chronic kidney disease (CKD) significantly elevates cardiovascular morbidity and mortality risks.
- Left ventricular hypertrophy (LVH) is a primary predictor of cardiovascular events in CKD patients.
Purpose of the Study:
- To compare echocardiographic left ventricular geometry in CKD patients versus non-CKD hypertensive and healthy controls.
- To investigate the association between CKD, left ventricular geometry, and estimated glomerular filtration rate (eGFR).
Main Methods:
- Analysis of 683 participants from the CRECKID STUDY: 220 CKD patients, 281 non-CKD hypertensive patients, and 182 healthy controls.
- Collection of demographic, clinical, and echocardiographic data.
Main Results:
- CKD patients showed significantly higher left atrial and left ventricular dimensions.
- Prevalence of LVH was highest in CKD patients (68.2%) compared to hypertensive (43.9%) and healthy (19.5%) groups.
- Lower eGFR was strongly associated with increased left ventricular mass (p<0.0001).
Conclusions:
- CKD patients present the highest prevalence of abnormal left ventricular geometry and function.
- Reduced eGFR correlates with increased left ventricular mass, emphasizing cardiovascular risk.
- Early detection and management of abnormal LV geometry are crucial for mitigating adverse cardiovascular outcomes in CKD.
Background:
Chronic kidney disease (CKD) is associated with increased risk of cardiovascular morbidity and mortality. Left ventricular hypertrophy (LVH) is considered the strongest independent predictor of cardiovascular disease and events among CKD patients. We reported the echocardiographic left ventricular geometry in CKD patients compared to non-CKD hypertensive and apparently healthy controls in Ibadan.
Materials And Methods:
A total of 683 participants in the CRECKID STUDY comprising 220(32.2%) CKD patients, 281(41.1%) non-CKD hypertensive patients and 182(26.6%) healthy controls were included in this analysis. Basic demographic and clinical information with echocardiographic parameters were obtained.
Results:
Study participants in the non-CKD hypertensive group were on average older than the CKD and the healthy controls (56.2±13.1 vs 47.2±14.6, and 46.8±13.3 years, respectively; p<0.01). Compared with other groups, greater proportions of participants with CKD were men (40.5% vs.38.1% and 21.3%; p<0.0001). The left atrial and left ventricular dimensions were significantly higher in CKD compared with others. LVH was significantly more prevalent among CKD patients (68.2%) compared to hypertensive (43.9%) and normotensive (19.5%) group (p<0.01). The participants with CKD had a greater proportion of abnormal LV geometry with concentric LVH predominating (p<0.0001). Having LVH was associated with lower mean estimated glomerular filtration rate (eGFR) (40.6±37.71 vs 67±37.38, p<0.0001).
Conclusion:
In our study, patients with CKD had the highest prevalence of abnormal LV geometry and functions. A unit decrease in eGFR was associated with increased left ventricular mass. Early detection and prompt management of abnormal LV geometry may help in reducing adverse cardiovascular outcome in patients with CKD.
Related Concept Videos
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
01:25Chronic Kidney Disease I: Introduction
01:24Chronic Kidney Disease II: Clinical Manifestations