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Successful Treatment of COVID-19-Related Immune- Complex Glomerulonephritis, Case Report

Ramazan Danis, Emrah Gunay1, Enver Yuksel

  • 1University of Health Sciences, Gazi Yasargil Training and Research Hospital, Nephrology Department , Diyarbakir, Turkey. egnay01@gmail.com.

Iranian Journal of Kidney Diseases
|April 30, 2022
PubMed

Insights

Coronavirus infection can cause immune-complex glomerulonephritis, leading to acute kidney injury. Early diagnosis and treatment with steroids are crucial for managing this post-COVID-19 complication.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Immunology

Background:

  • Coronavirus disease (COVID-19) has been associated with various renal complications.
  • Acute kidney injury (AKI), proteinuria, and hematuria are potential manifestations of COVID-19.

Observation:

  • A 59-year-old male developed rapidly progressive kidney failure with pulmonary hemorrhage two months post-COVID-19 infection.
  • Kidney biopsy revealed immune-complex glomerulonephritis, consistent with post-infectious glomerulonephritis.
  • The patient presented with AKI and nephrotic syndrome, requiring hemodialysis.

Findings:

  • Treatment included cyclophosphamide, methylprednisolone, and plasmapheresis initially.
  • Subsequent treatment focused on methylprednisolone, with cyclophosphamide and plasmapheresis discontinued.
  • The patient's condition improved with continued steroid therapy and supportive care.

Implications:

  • Immune-complex glomerulonephritis is a recognized complication following COVID-19 infection.
  • Prompt diagnosis and management, including steroid therapy, are essential for favorable outcomes.
  • This case highlights the importance of considering glomerulonephritis in patients with renal dysfunction after COVID-19.

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