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Updated: Sep 25, 2025

Isolation of Human Islets from Partially Pancreatectomized Patients
Published on: July 30, 2011
Pharmacological management of patients undergoing total pancreatectomy with auto-islet transplantation
Kristen R Szempruch1, Krysta Walter2, Natassha Ebert1
1Pharmacy Department, University of North Carolina Medical Center, Chapel Hill, NC, USA.
Abstract:
Chronic pancreatitis results in permanent parenchymal destruction of the pancreas gland leading to anatomical and physiological consequences for patients. Surgical management varies, and some patients require total pancreatectomy with autologous islet cell transplantation (TPIAT). Patients undergoing TPIAT require complex and diligent management after surgery. This encompasses the management of glucose control (endocrine function of the pancreas) and supplementing loss of exocrine function of the pancreas with digestive enzymes. Other areas of management include optimizing pain relief while reducing narcotic usage, providing antimicrobial prophylaxis, and reducing loss of islet cells by improving its integrity through anticoagulation and use of anti-inflammatory agents. Each aspect of care is unique to this population. However, comprehensive reviews on its pharmacological management are scarce. This review will discuss the available literature to date surrounding all aspects of pharmacological management of patients undergoing TPIAT.
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