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Published on: November 20, 2015
Impaired renal clearance among Swedish adolescents born preterm
Carin Skogastierna1, Anders Elfvin1,2, Sverker Hansson1
1Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Insights
Children born extremely preterm (before 28 weeks) face a higher risk of impaired kidney function in adolescence. Regular kidney function assessments are recommended for these individuals.
Area of Science:
- Pediatrics
- Nephrology
- Neonatology
Background:
- Infants born before 28 gestational weeks are a vulnerable population.
- Long-term health outcomes, particularly renal function, require ongoing investigation.
Purpose of the Study:
- To assess the risk of renal impairment in adolescents born extremely preterm.
- To evaluate kidney function in individuals born before 28 gestational weeks.
Main Methods:
- A cohort of Swedish infants born before 28 gestational weeks in 2001-2002 was identified.
- Renal function was assessed at 16-17 years of age using 51Cr-EDTA clearance.
- A comparison group of 26 individuals was included.
Main Results:
- 25% of the extremely preterm group (4/16) exhibited reduced kidney function (51Cr-EDTA clearance < 90 ml/min/1.73 m²).
- Kidney function was significantly lower in the study group compared to the control group (p=0.0012).
- 31% of participants required further medical investigation.
Conclusions:
- Adolescents born before 28 gestational weeks have an elevated risk of developing renal impairment.
- Routine assessment of kidney function is advised for this population during adolescence.
Aim:
To determine whether adolescents born before 28 gestational weeks have an increased risk for renal impairment.
Methods:
Swedish infants, born before 28 gestational weeks in 2001 and 2002, were identified from a local register. A total of 16 children, 12 females and 4 males, were examined at 16-17 years of age with 51 Cr-EDTA clearance. A comparison group (n = 26) was used.
Results:
Most study participants (n = 13) had normal blood pressure; one individual had hypertension stage 1. All study participants had results within the reference interval for ionised calcium, parathyroid hormone, intact fibroblast growth factor-23 and for urinary albumin-to-creatinine ratio. Four out of 16 participants (25%) had a 51 Cr-EDTA clearance less than 90 ml/min/1.73 m2 , indicating a reduced kidney function. Measured 51 Cr-EDTA clearance values were significantly lower in the study group than in the comparison group (p = 0.0012). Five study participants (31%) were referred for further investigations.
Conclusion:
Swedish children born before 28 gestational weeks have an increased risk of renal impairment later in life, suggesting that the kidney function in these individuals should be assessed, at least once, during adolescence.
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