PPAR-δ: A key nuclear receptor in vascular function and remodeling

Area of Science:

• Vascular Biology and Pathology
• Molecular Endocrinology
• Cardiovascular Medicine

Background:

• Vascular function is vital for homeostasis, regulated by intricate interactions.
• Cardiovascular risks trigger inflammation and oxidative stress, impairing vascular function and causing remodeling.
• Peroxisome proliferator-activated receptor-δ (PPAR-δ) is a nuclear receptor influencing cell growth, metabolism, and healing.

Purpose of the Study:

• To review recent advances on the functional roles of PPAR-δ in vascular biology.
• To highlight PPAR-δ's significance in regulating vascular homeostasis.
• To discuss PPAR-δ as a potential therapeutic target for cardiovascular diseases.

Main Methods:

• Literature review of recent scientific publications.
• Analysis of studies investigating PPAR-δ expression and function in vascular cells (endothelial cells, smooth muscle cells, monocytes).
• Synthesis of evidence on PPAR-δ's role in vascular homeostasis and disease.

Main Results:

• PPAR-δ is expressed in key vascular cell types.
• PPAR-δ exhibits pleiotropic effects in vascular health and disease.
• Emerging evidence points to PPAR-δ's critical regulatory role in vascular homeostasis.

Conclusions:

• PPAR-δ is a crucial regulator of vascular homeostasis.
• PPAR-δ represents a promising therapeutic target for cardiovascular disease intervention.
• Further research into PPAR-δ pathways could yield novel treatment strategies.