Related Experiment Video
Updated: Sep 25, 2025

In Vitro Characterization of Histone Chaperones using Analytical, Pull-Down and Chaperoning Assays
Published on: December 29, 2021
Structural and Functional Features of Viral Chaperonins.
Lidia P Kurochkina1, Pavel I Semenyuk2, Olga S Sokolova3
1Belozersky Research Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, Russia. lpk56@mail.ru.
Chaperonins, essential for protein folding, were discovered in bacteriophages, challenging previous understanding. This review details novel double-ring and single-ring phage chaperonins, comparing their structures and functions.
Area of Science:
- Molecular Biology
- Virology
- Structural Biology
Background:
- Chaperonins are crucial for protein folding in prokaryotes, eukaryotes, and archaea.
- Previously, chaperonins were not known to be encoded by viruses.
Purpose of the Study:
- To investigate the newly discovered chaperonins encoded by bacteriophages.
- To characterize the biochemical properties and structures of these novel phage chaperonins.
Main Methods:
- Comparative analysis of structural and biochemical properties.
- Review of existing research on phage-encoded chaperonins.
Main Results:
- Identification and initial characterization of double-ring (EL) and single-ring (OBP, AR9) phage chaperonins.
- Comparison of phage chaperonins with known Group I and Group II chaperonins.
Conclusions:
- Bacteriophages encode a novel group of chaperonins with unique structural features.
- These findings expand the known diversity of chaperonin proteins and their biological roles.
More Related Videos
08:29Averaging of Viral Envelope Glycoprotein Spikes from Electron Cryotomography Reconstructions using Jsubtomo
Published on: October 21, 2014
10:50Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding
Published on: September 15, 2010
Related Concept Videos
Viral Structure
Molecular Chaperones and Protein Folding
The...
Protein Complex Assembly
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Size and Structure of Viral Genomes
Introduction to Virus
Bacterial Protein Maturation