Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

1.0K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.0K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

184
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
184
Liver Histology01:27

Liver Histology

1.8K
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
1.8K
Esophageal Varices-I: Introduction01:24

Esophageal Varices-I: Introduction

394
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
394
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

362
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
362
Gross Anatomy of the Liver01:17

Gross Anatomy of the Liver

919
The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
919

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Variability in Clinical Performance of the FDA-Cleared Lumipulse P-Tau217/β-Amyloid 1-42 Plasma Ratio.

JAMA neurology·2026
Same author

Post-traumatic growth following the death of a parent from homicide: A reflective perspective from adulthood.

Death studies·2025
Same author

Standardized Perioperative Protocols and Variance in Pediatric Surgery.

JAMA surgery·2025
Same author

Retrospective analysis of vascular surgery complication rates compared to commonly used risk index calculators.

Journal of vascular surgery·2025
Same author

Northern peatland microbial communities exhibit resistance to warming and acquire electron acceptors from soil organic matter.

Nature communications·2025
Same author

Neural circuit mechanisms for steering control in walking <i>Drosophila</i>.

eLife·2025
Same journal

Care Transitions Continue to Evolve.

The Medical clinics of North America·2026
Same journal

Navigating the Gaps: A Comprehensive Overview of Care Transitions Across the Continuum.

The Medical clinics of North America·2026
Same journal

Care Transitions and Value-Based Payment Models in the United States.

The Medical clinics of North America·2026
Same journal

Technology and Innovation in Care Transitions: Imagining the Future of Postdischarge Care.

The Medical clinics of North America·2026
Same journal

Primary Care, Specialists, and Hospitals: Bridging the Gaps in Communication and Coordination.

The Medical clinics of North America·2026
Same journal

Social Determinants of Health: Unique Considerations in Transitions of Care.

The Medical clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Sep 25, 2025

Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration
10:42

Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration

Published on: May 13, 2016

9.3K

Cirrhosis.

Rachel Wilson1, Donna M Williams2

  • 1University of Wisconsin School of Medicine and Public Health, 2828 Marshall Court, Suite 100, Madison, WI 53705, USA.

The Medical Clinics of North America
|May 1, 2022
PubMed
Summary
This summary is machine-generated.

Cirrhosis, a chronic liver disease, presents with various physical signs. Recognizing specific findings like jaundice and ascites is crucial for assessing disease severity and complications.

Keywords:
AscitesCirrhosisEdemaEncephalopathyJaundiceLiverPhysical examinationSpider nevi

More Related Videos

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

52.9K
Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube
06:12

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

Published on: April 28, 2020

11.5K

Related Experiment Videos

Last Updated: Sep 25, 2025

Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration
10:42

Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration

Published on: May 13, 2016

9.3K
Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

52.9K
Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube
06:12

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

Published on: April 28, 2020

11.5K

Area of Science:

  • Hepatology
  • Internal Medicine
  • Clinical Examination

Background:

  • Cirrhosis is a severe, chronic liver condition characterized by inflammation and fibrosis.
  • Physical examination findings in cirrhosis can indicate disease severity and complications.
  • While some signs are nonspecific, others are highly indicative of advanced liver disease.

Purpose of the Study:

  • To discuss key physical examination findings in patients with cirrhosis.
  • To highlight specific signs that suggest complications of liver disease.
  • To provide a comprehensive overview of clinical manifestations in cirrhosis.

Main Methods:

  • Review of literature on physical examination findings in cirrhosis.
  • Discussion of specific clinical signs and their significance.
  • Categorization of findings based on their specificity and relation to complications.

Main Results:

  • Hepatomegaly and splenomegaly are common findings, reflecting liver and portal vein congestion.
  • Jaundice, ascites, and encephalopathy indicate significant liver dysfunction and portal hypertension.
  • Cutaneous signs such as spider nevi, palmar erythema, and dilated abdominal veins are characteristic of advanced cirrhosis.

Conclusions:

  • Physical examination is vital for assessing cirrhosis severity and identifying complications.
  • Specific findings like jaundice, ascites, and encephalopathy require prompt management.
  • A thorough physical assessment aids in the clinical staging and management of patients with liver cirrhosis.