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Canine intracranial meningioma with rosette-like collagen deposits
Ryo Saito1, James K Chambers1, Yoshiki Sugiyama2
1Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Abstract:
A 13-year-old female Miniature Dachshund showed seizures and an intracranial mass was seen in the left temporal lobe. Three months after first surgical resection, a recurrence lesion was recognized. Histopathologically, proliferation of spindle cells with diffuse rosette-like eosinophilic deposits, which stained blue with Masson's trichrome stain, was observed. In electron microscopy, the rosette-like deposits were consisted of bundles of minute filaments which were assumed to be collagenous fibrils. Immunohistochemically, the neoplastic cells were positive for vimentin and cytokeratin, and negative for E-cadherin, S100, glial fibrillary acidic protein (GFAP), oligodendrocyte transcription factor (Olig2), and CD204. The rosette-like collagen deposits were positive for type 4 collagen and negative for type 1 collagen. In this report, we describe histopathological features of a canine meningioma with the rosette-like collagen deposits.
Insights
This study details a canine meningioma in a Miniature Dachshund, characterized by unique rosette-like collagen deposits. These findings offer new insights into the histopathology of brain tumors in dogs.
Area of Science:
- Veterinary Pathology
- Canine Neuro-oncology
- Comparative Oncology
Background:
- Meningiomas are common primary brain tumors in dogs.
- Recurrence after surgical resection necessitates detailed histopathological analysis for accurate diagnosis and prognosis.
Observation:
- A 13-year-old Miniature Dachshund presented with seizures and an intracranial mass.
- Histopathology revealed spindle cell proliferation with distinctive rosette-like eosinophilic deposits, confirmed as collagen by electron microscopy.
- Immunohistochemistry showed neoplastic cells positive for vimentin and cytokeratin, with collagen deposits positive for type 4 collagen.
Findings:
- The canine meningioma exhibited unusual rosette-like collagen deposits, a feature not previously well-described.
- The neoplastic cells expressed markers consistent with meningioma, while the collagen deposits showed specific collagen type 4 positivity.
Implications:
- This case expands the understanding of meningioma histopathological variations in canines.
- Identifying unique collagen deposits may aid in diagnosing challenging canine brain tumors.
- Further research into these collagenous features could inform future therapeutic strategies for canine meningiomas.
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