Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

751
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
751
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

693
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
693
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

1.8K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.8K
Dementia01:30

Dementia

188
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
188
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

272
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
272
Neural Regulation01:37

Neural Regulation

40.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
40.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiple origins of the spinocerebellar ataxia 7 (SCA7) mutation revealed by linkage disequilibrium studies with closely flanking markers, including an intragenic polymorphism (G3145TG/A3145TG).

European journal of human genetics : EJHG·1999
Same author

Levodopa in the treatment of Parkinson's disease: a consensus meeting.

Movement disorders : official journal of the Movement Disorder Society·1999
Same author

Incubation period of Creutzfeldt-Jakob disease in human growth hormone recipients in France.

Neurology·1999
Same author

Dopaminergic cell group A8 in the monkey: anatomical organization and projections to the striatum.

The Journal of comparative neurology·1999
Same author

The phenomenology of L-dopa-induced dyskinesias in Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society·1999
Same author

Dyskinesias assessment in Phase II studies.

Movement disorders : official journal of the Movement Disorder Society·1999
Same journal

Geographic disparities in MRI features of ischemic stroke and small vessel disease: A comparative study between French Guiana and mainland France. Findings from the BECATOUR multicenter registry.

Revue neurologique·2026
Same journal

Continuous subcutaneous perfusion of apomorphine in Parkinson's disease: Towards monotherapy?

Revue neurologique·2026
Same journal

Neuro-Whipple presenting as autoimmune encephalitis.

Revue neurologique·2026
Same journal

Multimodal assessment of minimally conscious state and cognitive motor dissociation in neurocritical care: A critical review.

Revue neurologique·2026
Same journal

Development of a new episodic memory assessment tool (NEM): Preliminary data and clinical perspectives.

Revue neurologique·2026
Same journal

Novel variants and rare clinical presentations in MFN2-related Charcot-Marie-Tooth disease: Insights from 10 families.

Revue neurologique·2026
See all related articles

Related Experiment Video

Updated: Sep 25, 2025

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

14.2K

Neurodegenerative disorders: Are we wrong?

Y Agid1

  • 1Paris Brain Institute, CHU Pitié-Salpêtrière, 83 boulevard de l'Hôpital, 75013 Paris, France.

Revue Neurologique
|May 1, 2022
PubMed
Summary
This summary is machine-generated.

Defining neurodegenerative disorders remains challenging, questioning diagnostic criteria, distinguishing from normal aging, and understanding underlying mechanisms. Current research approaches may need re-evaluation to address these complex issues.

Keywords:
Biochemical abnormalitiesDiagnosisHistopathological stigmataNeurodegenerative disorderNeuronal lossTreatments

More Related Videos

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

17.6K
A Behavioral Test Battery for the Repeated Assessment of Motor Skills, Mood, and Cognition in Mice
07:18

A Behavioral Test Battery for the Repeated Assessment of Motor Skills, Mood, and Cognition in Mice

Published on: March 2, 2019

19.3K

Related Experiment Videos

Last Updated: Sep 25, 2025

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

14.2K
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

17.6K
A Behavioral Test Battery for the Repeated Assessment of Motor Skills, Mood, and Cognition in Mice
07:18

A Behavioral Test Battery for the Repeated Assessment of Motor Skills, Mood, and Cognition in Mice

Published on: March 2, 2019

19.3K

Area of Science:

  • Neurology
  • Neuroscience
  • Gerontology

Background:

  • Defining neurodegenerative disorders presents significant challenges.
  • Distinguishing disease symptoms from normal nervous system aging is difficult.
  • Understanding the mechanisms and causes of these disorders is complex.

Purpose of the Study:

  • To highlight the difficulties in defining and diagnosing neurodegenerative disorders.
  • To question current research paradigms.
  • To encourage a new perspective on neurodegenerative disease research.

Main Methods:

  • This work is a conceptual analysis and discussion.
  • It poses critical questions regarding diagnosis, mechanisms, and causes.
  • It reviews the limitations of current treatment research.

Main Results:

  • The definition and diagnosis of neurodegenerative disorders are not straightforward.
  • Existing research approaches have not yielded successful curative or preventive treatments.
  • A re-evaluation of research perspectives is necessary.

Conclusions:

  • There is a need for a fundamental re-evaluation of how neurodegenerative disorders are defined and researched.
  • Future research should explore novel angles to overcome current limitations.
  • Addressing the core questions is crucial for advancing the field.