Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

693
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
693
Dementia01:30

Dementia

188
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
188
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

272
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
272
Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

218
Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
218
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

4.1K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
4.1K
Stress: General Loading Conditions01:15

Stress: General Loading Conditions

385
To grasp the intricacy of real-world conditions where multiple loads are applied simultaneously to a structure, one might visualize a section passing through a specific point within a body, aligned parallel to the xy plane. This section is subjected to various forces, including original loads, normal forces, and shearing forces.
The shearing force, possessing potential directionality within the plane of the section, is simplified into two component forces running parallel to the x and y axes....
385

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The include network: Advancing cross-linguistic equity in brain health research.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Semantic memory navigation in mild cognitive impairment: Automated markers with neural and biofluid correlates.

NeuroImage·2026
Same author

Mind Melodies: An NLP platform to examine music cognition.

Behavior research methods·2026
Same author

Redefining the norms: an interdisciplinary perspective on language testing in multilinguals with acquired and progressive neurogenic disorders.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

Social vulnerability shapes deep clinical phenotypes and brain health in aging and dementia across Latin America.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Cross-Linguistic Insights From the Boston Naming Test: Structural Comparability and Performance Comparisons of English and Korean Speakers With Aphasia.

American journal of speech-language pathology·2026

Related Experiment Video

Updated: Sep 25, 2025

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

19.0K

Allostatic-Interoceptive Overload in Frontotemporal Dementia.

Agustina Birba1, Hernando Santamaría-García2, Pavel Prado3

  • 1Latin American Brain Health Institute, Universidad Adolfo Ibáñez, Santiago, Chile; National Scientific and Technical Research Council, Buenos Aires, Argentina; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina.

Biological Psychiatry
|May 1, 2022
PubMed
Summary
This summary is machine-generated.

Behavioral variant frontotemporal dementia (bvFTD) may involve an allostatic-interoceptive overload. This overload is evident in electrophysiological markers, brain changes, and cognitive deficits, impacting autonomic regulation and body sensing.

Keywords:
AllostasisAllostatic-interoceptive networkFrontotemporal dementiaHEPInteroceptionMultimodal imagingPredictive codingrsHEP

More Related Videos

Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging
10:25

Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging

Published on: June 5, 2017

14.2K
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

367

Related Experiment Videos

Last Updated: Sep 25, 2025

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

19.0K
Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging
10:25

Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging

Published on: June 5, 2017

14.2K
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

367

Area of Science:

  • Neuroscience
  • Cognitive Neurology
  • Psychiatry

Background:

  • Predictive coding theory posits that brain networks regulate the internal milieu to anticipate future needs.
  • The allostatic-interoceptive network (AIN) is crucial for autonomic regulation and interoceptive-exteroceptive balance.
  • Behavioral variant frontotemporal dementia (bvFTD) shows compromised AIN function, potentially indicating an allostatic-interoceptive overload.

Purpose of the Study:

  • To investigate the hypothesis that bvFTD is characterized by an allostatic-interoceptive overload.
  • To assess resting-state heartbeat evoked potential (rsHEP) modulation and its correlates in bvFTD.

Main Methods:

  • Assessed rsHEP modulation using resting-state electroencephalography in bvFTD, Alzheimer's disease, and healthy controls.
  • Examined rsHEP associations with neural generators, cognitive disturbances, brain atrophy, and AIN functional connectivity.
  • Utilized multimodal neuroimaging and machine learning for group prediction.

Main Results:

  • Patients with bvFTD exhibited more negative rsHEP amplitudes originating from key AIN hubs (insula, amygdala, somatosensory cortex, hippocampus, ACC).
  • Exacerbated rsHEP modulation in bvFTD predicted cognitive decline, executive dysfunction, and emotional impairments.
  • Increased rsHEP modulation correlated with reduced AIN brain volume and connectivity in bvFTD.

Conclusions:

  • bvFTD may be characterized by an allostatic-interoceptive overload.
  • This overload is reflected in electrophysiological markers, brain atrophy, functional network alterations, and cognitive deficits.
  • AIN specificity was confirmed in predicting the bvFTD group using machine learning.