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Updated: Sep 25, 2025
Production and Detection of Reactive Oxygen Species ROS in Cancers
Published on: November 21, 2011
The role of reactive oxygen species in tumor treatment
Pengpeng Jia1, Chenyu Dai1, Penghui Cao1
1Institute of Bismuth Science, University of Shanghai for Science and Technology Shanghai 200093 China ouyangrz@usst.edu.cn.
Abstract:
Reactive oxygen species (ROS) are by-products of aerobic metabolism and can also act as signaling molecules to participate in multiple regulation of biological and physiological processes. The occurrence, growth and metastasis of tumors, and even the apoptosis, necrosis and autophagy of tumor cells are all closely related to ROS. However, ROS levels in the body are usually maintained at a stable status. ROS produced by oxidative stress can cause damage to cell lipids, protein and DNA. In recent years, ROS have achieved satisfactory results on the treatment of tumors. Therefore, this review summarizes some research results of tumor treatments from the perspective of ROS in recent years, and analyzes how to achieve the mechanism of inhibition and treatment of tumors by ROS or how to affect the tumor microenvironment by influencing ROS. At the same time, the detection methods of ROS, problems encountered in the research process and solutions are also summarized. The purpose of this review is to provide a clearer understanding of the ROS role in tumor treatment, so that researchers might have more inspiration and thoughts for cancer prevention and treatment in the next stage.
Insights
Reactive oxygen species (ROS) are crucial signaling molecules involved in cancer. This review explores how manipulating ROS levels offers promising strategies for tumor treatment and prevention.
Area of Science:
- Biochemistry
- Oncology
- Cell Biology
Background:
- Reactive oxygen species (ROS) are metabolic by-products and signaling molecules regulating biological processes.
- Tumor occurrence, growth, metastasis, and cell death (apoptosis, necrosis, autophagy) are closely linked to ROS.
- While ROS are essential for homeostasis, oxidative stress-induced ROS can damage cellular components.
Purpose of the Study:
- To review recent research on tumor treatments utilizing ROS.
- To analyze mechanisms by which ROS inhibit tumors and affect the tumor microenvironment.
- To summarize ROS detection methods, challenges, and solutions in cancer research.
Main Methods:
- Literature review of recent studies on ROS and cancer treatment.
- Analysis of ROS-mediated anti-tumor mechanisms.
- Summary of ROS detection techniques and research challenges.
Main Results:
- ROS play a dual role in cancer, acting as both signaling molecules and damaging agents.
- Targeting ROS levels has shown significant potential in cancer therapy.
- Understanding ROS dynamics is key to developing effective cancer treatments.
Conclusions:
- Manipulating ROS presents a viable strategy for cancer treatment.
- Further research into ROS detection and modulation can inspire novel cancer prevention and therapy approaches.
- This review provides insights into the complex role of ROS in oncology.
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