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Updated: Sep 25, 2025

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
Published on: September 18, 2016
Copper-mediated construction of benzothieno[3,2-b]benzofurans by intramolecular dehydrogenative C-O coupling reaction
Liankun Ai1, Ibrahim Yusuf Ajibola1, Baolin Li1
1School of Chemical Sciences, University of Chinese Academy of Sciences Beijing 100049 P. R. China libl@ucas.ac.cn.
Abstract:
An efficient method to synthesize benzothieno[3,2-b]benzofurans via intramolecular dehydrogenative C-H/O-H coupling has been developed. Good to excellent yields (64-91%) could be obtained no matter if the substituted group is electron-donating or electron-withdrawing. Notably, three-to-six fused ring thienofuran compounds could be constructed using this method. A reaction mechanism study showed that 1,1-diphenylethylene can completely inhibit the reaction. Therefore, it is a radical pathway initiated by single electron transfer between the hydroxyl of the substrate and the copper catalyst.
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