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Updated: Sep 25, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Solvent-free and room temperature microwave-assisted direct C7 allylation of indolines via sequential C-H and C-C
Qiuling Wang1, Linlin Shi1, Shuang Liu1
1College of Chemistry, Zhengzhou University No. 100 of Science Road Zhengzhou Henan 450001 P. R. China zhuxinju@zzu.edu.cn mpsong@zzu.edu.cn.
Abstract:
A Ru or Rh-catalyzed efficient and atom-economic C7 allylation of indolines with vinylcyclopropanes was developed via sequential C-H and C-C activation. A wide range of substrates were well tolerated to afford the corresponding allylated indolines in high yields and E/Z selectivities under microwave irradiation. The obtained allylated indolines could further undergo transformations to afford various value-added chemicals. Importantly, this reaction proceeded at room temperature under solvent-free conditions.
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