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Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
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The Ror-Family Receptors in Development, Tissue Regeneration and Age-Related Disease

Mitsuharu Endo1, Koki Kamizaki1, Yasuhiro Minami1

  • 1Division of Cell Physiology, Department of Physiology and Cell Biology, Graduate School of Medicine, Kobe University, Kobe, Japan.

Frontiers in Cell and Developmental Biology
|May 2, 2022
PubMed

Insights

Ror1 and Ror2 proteins are key in development and tissue repair by mediating Wnt signaling. Dysregulation of Ror1/Ror2 is linked to aging, disease, and cancer, suggesting therapeutic potential.

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Regenerative Medicine

Background:

  • Ror1 and Ror2 are receptors for Wnt5a, activating non-canonical Wnt signaling.
  • This signaling pathway is crucial for cell polarity, migration, proliferation, and differentiation during development and tissue regeneration.

Purpose of the Study:

  • To review the roles of Ror1 and Ror2 signaling in development, tissue regeneration, and age-related diseases.
  • To discuss the therapeutic potential of Ror1 and Ror2 in chronic inflammatory diseases and cancers.

Main Methods:

  • Literature review of studies on Ror1 and Ror2 function.
  • Analysis of Ror1 and Ror2 expression patterns in developing and adult tissues.
  • Examination of Ror1 and Ror2 involvement in disease pathogenesis.

Main Results:

  • Ror1/Ror2 are essential for embryonic development and adult tissue repair.
  • Their expression is altered in aged tissues, contributing to senescence and impaired regeneration.
  • Enhanced Ror1/Ror2 expression is observed in age-related diseases like fibrosis, atherosclerosis, neurodegeneration, and cancer.

Conclusions:

  • Ror1 and Ror2 signaling plays critical roles in development, regeneration, and disease.
  • Dysregulation of Ror1/Ror2 contributes to aging and various pathologies.
  • Targeting Ror1/Ror2 pathways offers potential therapeutic strategies for inflammatory diseases and cancers.
Keywords:
cancerscell polaritycellular senescenceinflammationmigrationnon-canonical wnt signalingproliferationstem/progenitor cells

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