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Related Concept Videos

Regulation of Stroke Volume01:27

Regulation of Stroke Volume

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The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
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The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse
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Lipocalin-2 and Cerebral Stroke.

Chao Luo1, Shuai Zhou1,2, Shi Yin1

  • 1Department of Neurosurgery, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.

Frontiers in Molecular Neuroscience
|May 2, 2022
PubMed
Summary

Lipocalin-2 (LCN-2) plays a key role in secondary brain damage after stroke. Understanding LCN-2

Keywords:
blood brain barriercentral nervous systemcerebral strokeiron dysregulationlipocalin-2 (LCN-2)neurovascular unit (NVU)secondary injury

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Area of Science:

  • Neuroscience
  • Pathology

Background:

  • Stroke is a prevalent and severe condition with increasing global incidence.
  • Secondary injuries post-stroke include cell death, neuroinflammation, blood-brain barrier disruption, oxidative stress, and neurovascular unit dysfunction.

Purpose of the Study:

  • To review the regulatory roles of Lipocalin-2 (LCN-2) in secondary injuries following stroke.
  • To explore the pathological mechanisms by which LCN-2 modulates stroke progression.
  • To highlight LCN-2 as a potential therapeutic target for stroke.

Main Methods:

  • Literature review of existing research on LCN-2 and stroke.
  • Analysis of LCN-2's involvement in various cellular processes and secondary injury pathways.
  • Examination of LCN-2's novel roles in central nervous system cells.

Main Results:

  • LCN-2 influences diverse cellular processes relevant to stroke.
  • Evidence links LCN-2 to secondary injury and disease in the central nervous system.
  • Novel functions of LCN-2 have been identified in neurons, microglia, astrocytes, and endothelial cells.

Conclusions:

  • LCN-2 is implicated in the neuropathology of stroke.
  • LCN-2 represents a promising target for understanding and potentially treating stroke.
  • Further research into LCN-2's mechanisms could lead to improved stroke therapies.