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Updated: Sep 25, 2025

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Silencing circOMA1 Inhibits Osteosarcoma Progression by Sponging miR-1294 to Regulate c-Myc Expression

Yubo Shi1, Yunyun Tian1, Xiangran Sun1

  • 1Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China.

Frontiers in Oncology
|May 2, 2022
PubMed
Abstract

Insights

Circular RNA circOMA1 is upregulated in osteosarcoma, promoting tumor growth by sponging miR-1294 and increasing c-Myc. circOMA1 may be a therapeutic target for osteosarcoma.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Circular RNAs (circRNAs) are implicated in cancer development.
  • The role of circOMA1 in osteosarcoma tumorigenesis remains uncharacterized.

Purpose of the Study:

  • To investigate the expression and function of circOMA1 in osteosarcoma.
  • To elucidate the molecular mechanism underlying circOMA1's role in osteosarcoma progression.

Main Methods:

  • Bioinformatic analysis identified circOMA1.
  • Quantitative reverse transcription PCR (qRT-PCR) assessed gene expression.
  • In vitro and in vivo functional assays evaluated circOMA1's role.
  • Luciferase reporter, RNA immunoprecipitation (RIP), and FISH assays confirmed molecular interactions.

Main Results:

  • circOMA1 was significantly upregulated in osteosarcoma tissues.
  • circOMA1 knockdown inhibited osteosarcoma cell proliferation and tumor growth.
  • circOMA1 acts as a molecular sponge for miR-1294, enhancing c-Myc expression.

Conclusions:

  • circOMA1 functions as an oncogene in osteosarcoma.
  • The circOMA1/miR-1294/c-Myc pathway drives osteosarcoma progression.
  • circOMA1 presents a potential therapeutic target for osteosarcoma treatment.
Keywords:
c-MyccircOMA1miR-1294osteosarcomaprogression

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