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Updated: Sep 25, 2025

One-pot Microwave-assisted Conversion of Anomeric Nitrate-esters to Trichloroacetimidates
Published on: January 15, 2018
Ti-superoxide catalyzed oxidative amidation of aldehydes with saccharin as nitrogen source: synthesis of primary
Rohit B Kamble1,2, Kishor D Mane1,2, Bapurao D Rupanawar1,2
1Chemical Engineering and Process Development Division, CSIR-National Chemical Laboratory Pune Maharashtra India-411 008 gm.suryavanshi@ncl.res.in.
Abstract:
A new heterogeneous catalytic system (Ti-superoxide/saccharin/TBHP) has been developed that efficiently catalyzes oxidative amidation of aldehydes to produce various primary amides. The protocol employs saccharin as amine source and was found to tolerate a wide range of substrates with different functional groups. Moderate to excellent yields, catalyst reusability and operational simplicity are the main highlights. A possible mechanism and the role of the catalyst in oxidative amidation have also been discussed.
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