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Diffuse pulmonary calcification in allergic bronchopulmonary aspergillosis

Johnny F Jaber1, Lauran Zeineddine2, Divya C Patel1

  • 1Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida Health, Gainesville, FL, 32608, USA.

Respiratory Medicine Case Reports
|May 2, 2022
PubMed

Insights

Allergic bronchopulmonary aspergillosis (ABPA) is a lung condition often seen in asthma patients. A case study highlights IgE positivity for Aspergillus fumigatus and pulmonary calcifications in a patient with asthma.

Area of Science:

  • Pulmonology
  • Allergy and Immunology
  • Radiology

Background:

  • Allergic bronchopulmonary aspergillosis (ABPA) is an inflammatory lung disease.
  • ABPA commonly affects individuals with asthma or cystic fibrosis.
  • Diagnosis relies on combined clinical, radiographic, and immunologic evidence.

Observation:

  • A 64-year-old male with persistent asthma presented with increased cough.
  • High-resolution computed tomography (HRCT) revealed diffuse bilateral pulmonary calcifications.
  • Laboratory tests showed IgE positivity for Aspergillus fumigatus.

Findings:

  • The patient's presentation and diagnostic findings are consistent with ABPA.
  • Pulmonary calcifications, while not a classic sign, were noted on HRCT.
  • Aspergillus fumigatus specific IgE confirmed sensitization.

Implications:

  • This case underscores the importance of considering ABPA in asthma patients with worsening symptoms.
  • Radiographic findings like diffuse calcifications may be associated with ABPA.
  • Early diagnosis and management of ABPA are crucial for preventing lung damage.
Keywords:
ABPAAllergyAspergillosisAsthmaRadiology

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